Characteristic and clinical significance of microRNA expression between 144 Uygur and Han women with endometrial carcinoma.
10.19723/j.issn.1671-167X.2020.03.026
- Author:
Xiao WANG
1
;
Dan HE
1
;
Wen Ting LI
2
;
Siyiti ADILA
2
;
Rui HAN
1
;
Ying DONG
1
Author Information
1. Department of Pathology, Peking University First Hospital, Beijing 100034, China.
2. Department of Pathology, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, China.
- Publication Type:Journal Article
- Keywords:
Carcinoma, endometrioid;
Endometrial carcinoma;
MicroRNAs
- MeSH:
Carcinoma, Endometrioid;
China;
Endometrial Neoplasms;
Ethnicity;
Female;
Humans;
MicroRNAs;
Real-Time Polymerase Chain Reaction
- From:
Journal of Peking University(Health Sciences)
2020;52(3):570-577
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the expression patterns of microRNA (miRNA) between 144 Uygur and Han women with endometrial carcinoma and to investigate their clinical significance.
METHODS:Taqman miRNA low-density array was used to compare miRNA profiles between Uygur and Han women with non-endometrioid endometrial carcinoma (NEEC). Five miRNAs were further analyzed in the 144 endometrial cancers including 62 Uygur and 82 Han samples via real-time PCR to determine their expression patterns.
RESULTS:MiRNA expression profiles revealed that many miRNAs overexpressed or downregula-ted in one ethnic group, but did not express or changed slightly in the other ethnic group. Further detection in the 144 endometrial cancers showed that miR-141, miR-200a, and miR-205 overexpressed in both ethnic groups. In Uygur endometrioid endometrial carcinoma (EEC), tumors with miR-141/200a overexpression tended to be more aggressive in behavior, whereas in the Han group, EEC with miR-200a overexpression was relative mild. However, the NEEC with miR-200a overexpression also had aggressive clinicopathologic features in the Han women. MiR-145 and miR-143 expressed differentially between Uygur and Han groups, they overexpressed in the former and decreased in the latter (P<0.05). In the Uygur women miR-145/143 increased significantly in NEEC and there was a trend that NEEC exhibiting favorable clinicopathologic factors had higher miR-145 expression, and was statistically significant in tumors with myometrial invasion less than 1/2 thickness (P=0.042). By contrary, miR-145/143 decreased in Han group and EEC with worse clinicopathologic variables had lower expression although without statistical significance. NEEC in Han group had no such tendency.
CONCLUSION:Uygur and Han women might have different miRNA expression profiles. MiR-141/200a/205 overexpressed in endometrial carcinomas and miR-141/200a might behave differently between these two ethnic groups as well as in EEC and in NEEC. Although miR-145/143 showed inverse expression patterns between Uygur and Han women with endometrial cancer, they all exerted tumor suppression effect on endometrial cancer.
