Prevention and treatment of indirect drug-induced liver toxicity
10.3969/j.issn.1001-5256.2022.08.040
- VernacularTitle:间接药物性肝毒性的预防与治疗
- Author:
Jinsheng GUO
1
Author Information
1. Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai Institute of Liver Diseases, Shanghai 200032, China
- Publication Type:Reviews
- Keywords:
Chemical and Drug Induced Liver Injury;
Indirect Drug-Induced Liver Injury;
Therapeutics
- From:
Journal of Clinical Hepatology
2022;38(8):1923-1926
- CountryChina
- Language:Chinese
-
Abstract:
Indirect drug-induced liver toxicity (IDLT) refers to the condition that the use of some therapeutic drugs may induce new liver diseases or exacerbate the original liver disease, with the phenotype of underlying or predisposed liver diseases. IDLT may induce persistent liver injury or even acute liver failure and affect the pharmacotherapy for tumor or other comorbidities, leading to the suspension or termination of ongoing chemotherapy, immunotherapy, and targeted therapy, and therefore, it should be taken seriously in clinical practice. This article elaborates on the mechanisms and prevention strategies of several types of IDLT.
