Role of transcription factor Yin Yang 1 in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.08.039
- VernacularTitle:转录因子阴阳1在肝细胞癌中的作用
- Author:
Jie ZHOU
1
;
Yunhao HUA
;
Xiaomei WANG
1
;
Junqi NIU
1
Author Information
1. Department of Hepatology, Center for Infectious Diseases and Pathogenic Biology, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Transcription Factors;
Zinc Fingers
- From:
Journal of Clinical Hepatology
2022;38(8):1918-1922
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) often has an insidious onset, and most patients are in the advanced stage and have lost the best opportunity for treatment at the time of diagnosis, resulting in a poor prognosis. As a multifunctional transcription factor, Yin Yang 1 (YY1) regulates the transcription of a variety of important genes and plays a key role in various tumors. Previous studies have shown that YY1 affects many biological behaviors such as proliferation, apoptosis, migration, and angiogenesis and is closely associated with drug resistance and poor prognosis of HCC. This article reviews the research advances in the role of YY1 in the development and progression of HCC, so as to provide a theoretical basis for the treatment of HCC.
