Functional cure of hepatitis B from the perspective of hepatitis B virus covalently closed circular DNA
10.3969/j.issn.1001-5256.2022.08.003
- VernacularTitle:从HBV cccDNA角度谈乙型肝炎的功能性治愈
- Author:
Juan CHEN
1
;
Ailong HUANG
1
Author Information
1. Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing 400016, China
- Publication Type:Discussions by Experts
- Keywords:
Hepatitis B;
DNA, Circular;
Molecular Targeted Therapy
- From:
Journal of Clinical Hepatology
2022;38(8):1716-1720
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is the template for HBV transcription and replication and exists stably in hepatocytes in the form of minichromosome. Based on the mechanism of cccDNA inactivation or clearance and the development of related drugs, this article introduces the current knowledge on the formation, transcription, and degradation of cccDNA and reviews the research advances in cccDNA-targeted drugs and biological techniques.
