Metabolic regulation of innate immunity in cancer
10.16438/j.0513-4870.2022-0525
- VernacularTitle:代谢调控肿瘤微环境固有免疫应答机制研究进展
- Author:
Yi-ze LI
1
;
Min HUANG
1
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100009, China
- Publication Type:Research Article
- Keywords:
tumor microenviroment;
innate immunity;
immunometabolism;
metabolite;
immunotherapy
- From:
Acta Pharmaceutica Sinica
2022;57(9):2622-2641
- CountryChina
- Language:Chinese
-
Abstract:
Innate immune system, a non-specific defense system formed after birth, is body's first line of defense against pathogens. Innate immunity also plays a key role in the tumor immunosurveillance. With the clinical success of cancer immunotherapy, the regulatory mechanism of innate immune cells in antitumor response has begun to draw increasing attention. Recently, it has been recognized that metabolic regulation plays a vital role in innate immunity, in particular in the tumor microenvironment where the metabolic reprogramming in cancer increases the complexity of immunometabolism yet also provides therapeutic vulnerabilities. This review summarizes the recent progress in understanding the metabolic regulation of the innate immune response. We discuss how metabolites of glucose, amino acids, lipid and nucleotide metabolism regulate the function of innate immune cells. We pay the special attention to the metabolic crosstalk between immune cells or tumor-immune cells in the tumor microenvironment. With the review, we hope to get a better understanding of metabolic regulation of antitumor immunity and provide basis for metabolism-targeted immunotherapy.
