Research progress on anti-tumor and tumor immunity of marine natural products
10.16438/j.0513-4870.2022-0518
- VernacularTitle:海洋来源天然成分在抗肿瘤及肿瘤免疫领域的研究进展
- Author:
Zi-jun OUYANG
1
;
Xiao-fan SUN
2
;
Hai-yan SUN
1
;
Yang SUN
2
Author Information
1. Institute of Marine Biomedicine, School of Food and Drug, Shenzhen Polytechnic, Shenzhen 518055, China
2. State Key Laboratory of Pharmaceutical Biotechnology, Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
rug of marine origin;
anti-tumor drug;
tumor immunity;
natural product;
signaling pathway
- From:
Acta Pharmaceutica Sinica
2022;57(9):2642-2653
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the oceans have provided an important source of highly promising new anti-tumor drugs for innovation and screening, with approximately 56% of biologically active compounds being discovered to have anti-tumor effects each year. In this study, we classified and summarized the approved drugs of marine origin in terms of anti-tumor therapy, and firstly, we briefly overviewed the role of the immune system in cancer pathogenesis and discussed the current dilemma of cancer immunotherapy and highlighted the main anti-tumor targets of marine drugs. Further, with a focus on tumor immunity, we classified and outlined the history of currently approved marine original drugs by species origin, structural features, relevant pathways, and clinical application and therapy. Lastly, the limitations of current marine drug research were discussed, as well as prospects and trends in new drug development.
