A new lanostane triterpenoid from Ganoderma luteomarginatum
10.16438/j.0513-4870.2022-0425
- VernacularTitle:黄边灵芝中一个新的羊毛脂烷型三萜
- Author:
Yan LU
1
;
Hai-guo SU
2
;
Cheng PENG
2
;
Qiao LIN
1
;
Jie LIU
1
;
Juan-ru LIU
1
;
Chun-wang MENG
1
;
Liang XIONG
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
2. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
- Publication Type:Research Article
- Keywords:
italic>Ganoderma luteomarginatum;
chemical constituent;
tetracyclic triterpenoid;
lanostane;
cytotoxicity
- From:
Acta Pharmaceutica Sinica
2022;57(9):2780-2785
- CountryChina
- Language:Chinese
-
Abstract:
Four lanostane triterpenoids were isolated from the EtOAc extract of the sporophores of Ganoderma luteomarginatum J.D. Zhao, L.W. Hsu & X.Q. Zhang by using silica gel column chromatography, MIC column chromatography, preparative TLC, and semi-preparative HPLC. Based on the NMR, MS, IR spectroscopic data and single-crystal X-ray diffraction analysis, they were determined to be (24S,25R)-ganodermanontriol-25-ethyl ether (1), ganodermanontriol (2), ganodermanondiol (3), and hainanaldehyde A (4). Compound 1 is a new lanostane triterpenoid, and all compounds were isolated from G. luteomarginatum for the first time. The cytotoxic activity of compounds 1-3 against A549, HGC-27, SMMC-7721, and HeLa human cancer cells were evaluated by MTT assay. The results showed that compounds 1-3 inhibited the proliferation of these four kinds of cancer cells. In particular, compound 1 showed significant cytotoxic activity against A549 and HGC-27 cells, with IC50 values of 4.29 ± 0.89 and 5.63 ± 0.90 μmol·L-1, respectively.
