A new polycyclic polyprenylated acylphloroglucinols from Hypericum lagarocladum N. Robson
10.16438/j.0513-4870.2022-0095
- VernacularTitle:纤枝金丝桃中的一个新的多环多异戊烯基间苯三酚衍生物
- Author:
Jing-tong DENG
1
;
Tong-xi ZHOU
2
;
Qing-di HAN
1
;
Hai-tao CHENG
1
;
Yang LIU
2
;
Qiang WANG
1
;
Xin-zhou YANG
1
Author Information
1. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China
2. College of Life Science, Wuchang University of Technology, Wuhan 430223, China
- Publication Type:Research Article
- Keywords:
Guttiferae;
italic>Hypericum lagarocladum N. Robson;
chemical component;
polycyclic polyprenylated acylphloroglucinol;
glucose uptake
- From:
Acta Pharmaceutica Sinica
2022;57(9):2767-2773
- CountryChina
- Language:Chinese
-
Abstract:
Silica gel column chromatography, reversed phase C18 column chromatography, Sephadex LH-20 gel column chromatography, high performance liquid chromatography and medium performance semi preparative liquid chromatography were performed to separate and purify the chemical constituents of Hypericum lagarocladum N. Robson. Spectroscopic methods such as MS and NMR combined with physicochemical properties were applied in identifying the structures of the isolated compounds. A total of 11 compounds were isolated and identified as hyperlagarone A (1), hyperpatulone E (2), hyperbeanol G (3), uralione D (4), tomoeone F (5), pyramidatone A (6), tomoeone A (7), tomoeone B (8), hyperbeanol C (9), hyperbeanol A (10), and hypercohone G (11), respectively. Compound 1 is a new polycyclic polyprenylated acylphloroglucinol derivative, and compounds 2-11 are isolated from this plant for the first time. 11 compounds were tested for glucose uptake in L6 cells, and the results showed that compounds 7 and 8 had significant effect on glucose uptake.
