Research progress on the role of programmed cell death in hepatic ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2022.05.015
- VernacularTitle:程序性细胞死亡在肝脏缺血-再灌注损伤中的作用研究进展
- Author:
Yang BAI
1
;
Jihua SHI
;
Shuijun ZHANG
Author Information
1. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
Hepatic ischemia-reperfusion injury;
Programmed cell death;
Apoptosis;
Autophagy;
Ferroptosis;
Necroptosis;
Pyroptosis;
Pathanatos
- From:
Organ Transplantation
2022;13(5):647-
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is an effective treatment for the end-stage liver disease. However, hepatic ischemia-reperfusion injury (HIRI) will inevitably occur during liver transplantation, which might lead to early graft dysfunction or aggravate rejection. The underlying protective mechanism remains to be further elucidated. Programmed cell death is an important mechanism of HIRI, and multiple novel types of programmed cell death participate in the pathological process of HIRI. In-depth study of programmed cell death is expected to further improve the therapeutic effect of liver transplantation. In this article, research progresses on apoptosis, autophagy and autophagy-dependent cell death, ferroptosis, necroptosis, pyroptosis, pathanatos and other common programmed cell death patterns in HIRI were reviewed, aiming to provide reference for enhancing the success rate of liver transplantation and improving clinical prognosis of the recipients.
