Increased risk of cardiovascular disease in elderly population with carotid plaque and low ankle brachial index.
10.3760/cma.j.cn112148-20200401-00272
- VernacularTitle:颈动脉斑块和低踝臂指数联合作用增加老年人缺血性心脑血管事件的发生风险
- Author:
Wen LI
1
;
Shuo Hua CHEN
2
;
Jian Qiu ZHAO
3
;
Tie Zhu SHEN
4
;
Xiao Qing LI
4
;
Yi Min JIANG
1
;
Shou Ling WU
2
Author Information
1. Department of Ultrasound,Shanghai Sixth People's Hospital,Shanghai 200030, China.
2. Kailuan Employee Security Center, Kailuan 063000, China.
3. Department of Anesthesia, Shanghai Jiading District Hospital, Shanghai 201805, China.
4. Department of Ultrasound, Kailuan General Hospital, Kailuan 063000, China.
- Publication Type:Journal Article
- From:
Chinese Journal of Cardiology
2021;49(3):263-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate whether the co-presence of carotid plaques and low ankle-brachial index (ABI) might increase the risks of ischemic cardiovascular and cerebrovascular event in elderly population. Methods: It was a prospective study. Participants from the elderly cohort of the Kailuan Study, who completed a carotid sonography and ABI examination, were included in this study. Participants underwent physical examinations between 2010 and 2011 and were divided into 3 groups: no carotid plaque and ABI>0.9 group (n=526), carotid plaque and ABI>0.9 group (n=1 067), and carotid plaques and ABI≤0.9 group (n=49). Follow up ended on the 31 December 2016. The incidence of ischemic cardiovascular and cerebrovascular event was compared between the 3 groups, the relationship between carotid plaque and low ABI with ischemic cardiovascular and cerebrovascular event was analyzed. Results: A total of 1 642 participants were included (age, (67.1±6.4) years). There were 1 028 males (62.6%) and 1 028 females(37.4%). The average follow-up time was 5.41 years, the incidence of ischemic cardiovascular and cerebrovascular event in the 3 group was 2.1%(11/526), 5.5%(59/1 067), and 12.2%(6/49),respectively; the incidence of myocardial infarction in the 3 group was 0.2%(1/526), 1.6%(17/1 067), 10.2%(5/49), respectively; the incidence of cerebral infarction in the 3 group was 1.9%(10/526), 3.9%(42/1 067) and 2.0%(1/49), respectively. Multivariate Cox risk proportional regression analysis showed that compared with the group without carotid plaque and ABI>0.9, the HR values (95%CI) of ischemic cardiovascular and cerebrovascular event in the group with carotid plaque and ABI>0.9, carotid plaques and ABI≤0.9 group were 3.52 (1.49-8.35), 7.16(2.11-24.26) respectively, after adjusting for sex,age,systolic blood pressure,fast blood glucose,body mass index,total cholesterol,smoke,alcohol consumption and lipid-lowering medication and antihypertensive medication. Conclusions: Co-presence of carotid plaques and low ankle-brachial index may further increase the risk of ischemic cardiovascular and cerebrovascular event among elderly population in this cohort.
