Carotid intraplaque neovascularization is correlated with the risk of revascularization following percutaneous coronary intervention.
10.12122/j.issn.1673-4254.2022.06.13
- Author:
Yan Yan HAN
1
;
Xiang FEI
2
;
Ling REN
2
;
Jing Jing WANG
1
;
Tao CHEN
1
;
Jun GUO
1
;
Qi WANG
1
Author Information
1. Department of Cardiology, Sixth Medical Center of Chinese PLA General Hospital, Beijing 100048, China.
2. Department of Ultrasound, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- Keywords:
carotid plaque;
contrast-enhanced ultrasound;
coronary artery disease;
intraplaque neovascularization;
revascularization
- MeSH:
Humans;
Neovascularization, Pathologic;
Percutaneous Coronary Intervention;
ROC Curve;
Risk Factors;
Vascular Surgical Procedures
- From:
Journal of Southern Medical University
2022;42(6):892-898
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the correlation of intraplaque neovascularization (IPN) detected by carotid contrast-enhanced ultrasound (CEUS) with revascularization in patients following percutaneous coronary intervention (PCI).
METHODS:This study was conducted among 105 patients who were followed up for more than 12 months after PCI. All the patients received CEUS examination for assessment of carotid plaque formation and IPN, which were compared between patients with revascularization (REV group, n=27) and those without revascularization (N-REV group, n=78). ROC curve was used to analyze the diagnostic efficacy of CEUS for predicting revascularization. Univariate and multivariate logistic regression analyses were performed to identify the risk factors associated with revascularization.
RESULTS:In the REV group, the IPN score was 0 in 1 (3.7%) patient, 1 in 8 (29.6%) patients, 2 in 15 (55.6%) patients and 3 in 3 (11.1%) patients. Significant differences were noted between REV and N-REV groups in plaque length (15.70±6.93 vs 12.10±6.64, P < 0.05), maximum plaque thickness (3.69±1.12 vs 3.14±1.18, P < 0.05) and IPN (1.74±0.71 vs 0.87±0.63, P < 0.001). IPN score was identified as an independent risk factor for revascularization in patients following PCI, and at the cutoff value of 1.5, its sensitivity, specificity, positive predictive value, and negative predictive value for predicting the occurrence of revascularization were 74%, 89%, 69%, and 91%, respectively, with an AUC of 0.848 (95% CI: 0.703-0.905, P < 0.001).
CONCLUSION:CEUS allows noninvasive and semi-quantitative assessment of neovascularization in carotid artery plaques, and IPN detected by CEUS is correlated with the risk of revascularization in patients following PCI.
