Anti-tumor Application and Pharmacological Mechanism of Xihuangwan： A Review
10.13422/j.cnki.syfjx.20220322
- VernacularTitle:西黄丸抗肿瘤临床应用及药理作用机制研究进展
- Author:
Yu-ting YANG
1
;
Jin ZENG
2
;
Ping CHEN
2
;
Meng-lie WANG
2
;
Zhu-jun YIN
2
;
Li LI
2
;
Ying DAI
2
;
Jun-ning ZHAO
1
;
Yong LI
3
;
Guo-liang WEN
3
Author Information
1. College Pharmacy， Chengdu University of Traditional Chinese Medicine（TCM）， Chengdu 611100， China
2. Translational Chinese Medicine Key Laboratory of Sichuan Province， Sichuan Academy of Chinese Medicine Sciences， Sichuan Institute for TCM， Chengdu， 610041， China
3. Sichuan Fengchun Pharmaceutical Co.Ltd.，Deyang 618000， China
- Publication Type:Journal Article
- Keywords:
Xihuangwan;
chemical components;
malignant tumors;
clinical research;
pharmacological mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(3):250-258
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors are currently seriously endangering human health and life， which has become one of the main causes of death in China. In modern Western medicine， they are mainly tackled by surgery， chemotherapy， and radiotherapy， but the death toll continues to rise year by year. At present， most of the anti-tumor chemotherapeutics used in clinical practice have toxic and side effects， affecting the anti-tumor efficacy and the conditions after treatment. Long-term medication will also induce drug resistance， making the good anti-tumor effect difficult to be achieved. With the vigorous development of traditional Chinese medicine （TCM）， it has played a crucial role in the fight against tumors. It is believed in TCM that "heat toxin" is one of the important causes of tumors. Therefore， the methods of clearing away heat and removing toxin are often emphasized in the treatment of tumors， and the resulting outcomes are satisfactory. There are many Chinese herbs and Chinese herbal compounds classified into the heat-clearing and toxin-removing type. Xihuangwan， a classic heat-clearing prescription， is composed of Calculus Bovis， Moschus， Olibanum， and Myrrh and has the effects of clearing away heat， removing toxin， eliminating edema， and dissipating mass， which is mainly used to treat carbuncle， pustule， scrofula， multiple abscess， and cancer caused by heat-toxin obstruction. In modern clinical practice， it has been employed in patients with lung cancer， breast cancer， gastric cancer， liver cancer， colorectal cancer， and other malignant tumors， especially during the advanced stage， as a routine or adjuvant treatment for alleviating their clinical symptoms and improving their quality of life. The main active components of Xihuangwan are pentacyclic triterpenoids （such as masticinic acids）， volatile oils， steroids （like porcine deoxycholic acid）， and bilirubin， which have been proved effective in anti-tumor. This paper reviewed the prescription source， pharmaceutical research， clinical anti-tumor research， and pharmacological mechanisms of Xihuangwan， which has provided reference for further expanding the anti-tumor applications of Xihuangwan and enhancing its secondary development.
