Effect of Chinese Medicine on Diabetic Wound Based on Nrf2 Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20220203
- VernacularTitle:基于Nrf2信号通路的中药促进糖尿病创面愈合研究进展
- Author:
Xin ZHOU
1
;
Peng LIU
1
;
Yan-ling GUO
1
;
Biao XU
1
;
Wen-jing NIU
1
;
Jun WANG
1
Author Information
1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM），National Clinical Research Center for Chinese Medicine Acupuncture Moxibustion，Tianjin 300193，China
- Publication Type:Journal Article
- Keywords:
diabetic wound;
nuclear factor erythroid 2-related factor 2 （Nrf2）;
oxidative stress;
Chinese medicine;
effective ingredients
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(3):241-249
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic wound healing disorder，one of the common chronic complications of diabetes，seriously influences the quality of life of patients and even causes disability and death，bringing a heavy burden to the society. Chinese medicine，a unique and precious resource in China，is safe with definite effect. Oxidative stress plays an important role in the occurrence and development of diabetic wound and the disturbance of antioxidant defense mechanism is among the causes of the lingering diabetic wound. As a vital transcription factor for intracellular redox homeostasis，nuclear factor erythroid 2-related factor 2 （Nrf2） regulates oxidative/heterogenous stress and reduces inflammatory responses. Although it is unnecessary for common wound healing，it is of great importance for diabetic wound healing. Many Chinese medicinals and the active ingredients have been found to enhance diabetic wound healing by mechanisms related to activation of the Nrf2 signaling pathway. Targeted activation of Nrf2 by Chinese medicine can alleviate oxidative stress，inflammatory response，and apoptosis in diabetic wound，thereby delaying further exacerbation of symptoms. Therefore，Nrf2 is regarded as a potential target for drugs to boost diabetic wound healing. This study summarizes the relationship between the Nrf2 signaling pathway and diabetic wound and analyzes the mode of action and possible mechanisms of Chinese medicine and its active ingredients in promoting diabetic wound healing through modulating the Nrf2 pathway，which is expected to serve as a reference for developing drugs for diabetic wound based on this pathway.
