Clinical Treatment of Insomnia with Syndrome of Qi Stagnation and Blood Stasis by Uyghur Medicine Yangxin Dawayimicol Honey Ointment
10.13422/j.cnki.syfjx.20220493
- VernacularTitle:养心达瓦依米西克蜜膏治疗气滞血瘀证失眠的临床观察
- Author:
Ke XUE
1
;
Shu-zhang YUAN
2
;
Lan-hua AN
2
;
Xiao-shan HUI
3
;
Jin-sheng ZHANG
4
Author Information
1. Xinxiang First People's Hospital，Xinxiang 453000，China
2. Henan University of Chinese Medicine，Zhengzhou 450046，China
3. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China
4. Third Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450008，China
- Publication Type:Journal Article
- Keywords:
Yangxin Dawayimicol Honey Ointment;
insomnia;
Qi stagnation and blood stasis syndrome;
clinical study
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(4):124-129
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the clinical efficacy and safety of Yangxin Dawayimicol honey ointment （YDHO） in the treatment of insomnia with the syndrome of Qi stagnation and blood stasis. MethodEighty insomnia patients who met the inclusion criteria in the Department of Encephalopathy of the Third Affiliated Hospital of Henan University of Chinese Medicine from November 2019 to October 2020 were randomly divided into an experimental group （48 cases） and a control group （32 cases）. The experimental group was treated with YDHO + Xuefu Zhuyu capsule simulators，and the control group was treated with Xuefu Zhuyu capsules + YDHO simulators for eight weeks. The changes in Pittsburgh sleep quality index（PSQI）score，traditional Chinese medicine （TCM） syndrome score，insomnia severity index （ISI），neurotransmitter indexes ［γ-aminobutyric acid（GABA），glutamic acid（Glu），and 5-hydroxy tryptamine（5-HT）］，serum inflammatory indexes ［interleukin-6（IL-6）and interleukin-10（IL-10）］， and safety index of the two groups were compared. ResultThe total effective rate was 97.83%（45/46） in the experimental group， higher than 68.75%（22/32） in the control group（Z=-4.292，P<0.01）. The experimental group was superior to the control group in PSQI score，ISI score，TCM syndrome score， and sleep duration（P<0.05）. The curative effects were equivalent between the two groups in shortening the time to fall asleep. The experimental group showed increased serum content of GABA，5-HT， and IL-10 and reduced content of Glu and IL-6，with few adverse reactions （P<0.05）. ConclusionYDHO is effective，safe， and reliable in the treatment of insomnia with Qi stagnation and blood stasis syndrome.
