Anti-tumor Effect and Mechanisms of Triterpenoids and Polysaccharides in Ganoderma lucidum： A Review
10.13422/j.cnki.syfjx.20220431
- VernacularTitle:灵芝三萜与灵芝多糖抗肿瘤作用及其机制研究进展
- Author:
Meng-chen WANG
1
;
Xue-lian ZHANG
1
;
Xiang-dong CHEN
1
;
Jin LAN
1
;
Fei WEI
1
;
Yun LUO
1
;
Xiao-bo SUN
1
Author Information
1. Institute of Medicinal Plant Development， Chinese Academy of Medical Sciences， Beijing 100193， China
- Publication Type:Review
- Keywords:
Ganoderma lucidum triterpenoids;
Ganoderma lucidum polysaccharides;
anti-tumor effect;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(5):234-241
- CountryChina
- Language:Chinese
-
Abstract:
With the population aging， the morbidity and mortality of cancer patients continue to rise. At present， the treatment methods for tumors include surgery， chemotherapy， radiotherapy， targeted therapy， and immunotherapy. However， most chemotherapeutic drugs can cause severe side effects and drug resistance. Therefore， as an alternative therapy， traditional Chinese medicine （TCM） treatment can effectively relieve the clinical symptoms of tumor patients， improve the quality of life， inhibit or stabilize the development of tumors， and prolong the survival period of patients. Due to the good safety of Chinese medicine， its potential anti-cancer activity has attracted increasing attention. Ganoderma lucidum， a treasure of Chinese medicinal material， is a medicinal fungus with a history of more than 2 000 years in China. So far， many studies have proposed the anti-cancer properties of G. lucidum. G. lucidum has extensive pharmacological activities， such as anti-tumor， anti-atherosclerosis， and anti-aging. It can also regulate immunity， protect the liver and the heart， and reduce blood glucose and lipid. The chemical composition of G. lucidum is complex. At present， it is proved to contain polysaccharides， triterpenoids， alkaloids， nucleosides， amino acids， and various trace elements. The anti-tumor mechanisms of polysaccharides and triterpenoids in G. lucidum are mainly achieved by apoptosis induction， immune regulation， anti-angiogenesis， and induction of cell cycle arrest. Currently， it has been widely used in the adjuvant treatment of complex tumors such as lung cancer， liver cancer， cervical cancer， prostate cancer， breast cancer， and colon cancer. The present study reviewed the bioactivities and mechanisms of triterpenoids and polysaccharides in G. lucidum in recent years and highlighted the anti-tumor effects and mechanisms to provide references for the further development and utilization of G. lucidum.
