Discussion on Role of Macrophage Polarization in Inflammation of Heart Failure Based on Yin-yang Theory
10.13422/j.cnki.syfjx.20211850
- VernacularTitle:基于阴阳学说探讨巨噬细胞极化在心力衰竭炎症中的作用
- Author:
Meng YANG
1
;
Lin LI
1
;
Hao LIANG
1
;
Sen-jie ZHONG
1
;
Jia-hao YE
1
;
Si-yuan HU
1
;
Zhi-xi HU
1
Author Information
1. College of Traditional Chinese Medicine， Hunan University of Chinese Medicine，Changsha 410208，China
- Publication Type:Journal Article
- Keywords:
heart failure;
Yin-yang theory;
macrophage polarization;
inflammation response;
traditional Chinese medicine;
microenvironment;
cardiac homeostasis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(5):219-226
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation is the key pathogenic feature of heart failure （HF）， and its overexpression can cause myocardial hypertrophy， apoptosis and fibrosis， aggravating the process of HF. Macrophages are important immune cells in human body with high heterogeneity， which involve in inflammation response and maintain heart homeostasis. Macrophage polarization is a dynamic process. Under the stimulation of different microenvironment， it can polarize two subsets， including classically activated M1 type and alternatively activated M2 type， which are antagonistic to each other. When macrophages polarize into the pro-inflammatory phenotype （M1）， the inflammatory response is initiated， the anti-inflammatory phenotype （M2） plays a role in inhibiting inflammation and repairing tissue. At the same time， in different stages of development of HF， M1 and M2 macrophages can be transformed into each other， which is similar to the connotation of Yin-yang restriction， balance and transformation of traditional Chinese medicine （TCM） theory. Based on this， this paper intends to clarify the relationship between M1 and M2 macrophages by Yin-yang theory， proposing that the clinical prevention and treatment of HF should pay attention to regulating micro and macro inflammatory responses， regulating macrophage polarization， and achieving the balance between anti-inflammatory and pro-inflammation， which is consistent with the balance of Yin-yang in TCM theory. It can provide a new target and direction for TCM treatment of HF.
