Common Problems of Traditional Chinese Medicine Effervescent Tablets and Prospect Analysis of Powder Modification Technology
10.13422/j.cnki.syfjx.20211869
- VernacularTitle:中药泡腾片常见问题及粉体改性解决策略的前景分析
- Author:
Xin-feng XIA
1
;
Mei WU
1
;
Fei WU
1
;
Xiao LIN
1
;
Ruo-fei DU
1
;
Li-jie ZHAO
1
;
Yi FENG
1
Author Information
1. Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine（TCM），Ministry of Education，School of Chinese Materia Medica， Shanghai University of TCM，Shanghai 201203，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine effervescent tablets;
powder modification technology;
hygroscopicity;
sticking;
flowability;
microencapsulation technology;
inclusion technology
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2022;28(9):266-272
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine （TCM） effervescent tablets have the characteristics of rapid disintegration， good taste， and convenient taking， but there are some technical difficulties in the preparation and storage process， which are mainly reflected in the sticking， easy moisture absorption， poor compressibility， and poor stability. The basic physical properties of TCM powder （extract powder， raw powder） are the main cause of these technical problems， and also the key to control the quality of TCM effervescent tablets. Powder modification technology has shown good effects in solving the above problems. The author intended to review the research in the above aspects in recent years， and proposed the following strategies for applying powder modification technology to solve the problems in the production process of TCM effervescent tablets from the three aspects of raw materials， excipients and preparation intermediates：①The application of co-processing technology to the treatment of raw materials and auxiliary materials can solve the problems of sticking， poor compressibility， delayed disintegration， and poor stability. ②Using surface coating technology to treat raw materials and preparation intermediates can improve poor fluidity， poor compressibility and delayed disintegration. ③The hygroscopicity of the preparation can be reduced by using microencapsulation technology to treat the raw material. ④The inclusion technology can improve the clarity and stability of the preparation.
