Research progress of the dopaminergic and cholinergic signaling pathways in myopia
10.3980/j.issn.1672-5123.2022.9.16
- VernacularTitle:多巴胺能与胆碱能通路在近视发生发展中的作用研究进展
- Author:
Xiao-Ling XIANG
1
;
Qin YANG
1
;
Chang-Jun LAN
1
;
Xuan LIAO
1
Author Information
1. Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China; Medical School of Ophthalmology & Optometry, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
- Publication Type:Journal Article
- Keywords:
myopia;
dopamine;
acetylcholine;
pathways
- From:
International Eye Science
2022;22(9):1500-1503
- CountryChina
- Language:Chinese
-
Abstract:
Myopia has become a global public health concern. However, its mechanism remains unclear. Dopamine and acetylcholine, as important neurotransmitters in retina, play a critical role in the formation and inhibition of experimental myopia by binding to specific receptors respectively. Simultaneously, the mechanisms of related signaling pathways during myopia have attracted much attention. Most studies have identified that dopamine and acetylcholine receptor antagonists could inhibit the development of experimental myopiato some extent. Furthermore, pharmacological experiments have suggested that the two signaling pathways cross and influence each other, and there may be common mediators. In this paper, we briefly reviewed the recent researches on dopaminergic and cholinergic signaling pathways and their association during myopia, to provide references for further insights into pathogenesis as well as the prevention and treatment of myopia.
