Discharge from the emergency department and early hospital revaluation in patients with COVID-19 pneumonia: a prospective study
	    		
		   		
		   			
		   		
	    	
    	- Author:
	        		
		        		
		        		
			        		Massimo MATTIOLI
			        		
			        		
			        		
			        			1
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Devis BENFAREMO
			        		
			        		;
		        		
		        		
		        		
			        		Francesca FULGENZI
			        		
			        		;
		        		
		        		
		        		
			        		Silvia GENNARINI
			        		
			        		;
		        		
		        		
		        		
			        		Luciano MUCCI
			        		
			        		;
		        		
		        		
		        		
			        		Flavia GIORGINO
			        		
			        		;
		        		
		        		
		        		
			        		Gabriele FRAUSINI
			        		
			        		;
		        		
		        		
		        		
			        		Gianluca MORONCINI
			        		
			        		;
		        		
		        		
		        		
			        		Umberto GNUDI
			        		
			        		
		        		
		        		
		        		
			        		
			        		Author Information
			        		
 - Publication Type:Original Article
 - From: Clinical and Experimental Emergency Medicine 2022;9(1):10-17
 - CountryRepublic of Korea
 - Language:English
 - 
		        	Abstract:
			       	
			       		
				        
				        	 Objective:The national health systems are currently facing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. We assessed the efficacy of outpatient management for patients with SARS-CoV-2 related pneumonia at risk of progression after discharge from the emergency department. 
				        	
Methods:This was a single-center prospective study. We enrolled patients with confirmed SARS-CoV-2 pneumonia, without hypoxemic respiratory failure, and at least one of the following: age ≥ 65 years or the presence of relevant comorbidities or pneumonia extension > 25% on high resolution computed tomography. Patients with pneumonia extension > 50% were excluded. An ambulatory visit was performed after at least 48 hours, when patients were either discharged, admitted, or deferred for a further visit. As a control, we evaluated a comparable historical cohort of hospitalized patients.
Results:A total of 84 patients were enrolled (51 male patients; mean age, 62.8 years). Two-thirds of the patients had at least one comorbidity and 41.6% had a lung involvement > 25% on high resolution computed tomography; the mean duration of symptoms was 8.0 ± 3.0 days, and the mean PaO2/FiO2 ratio was 357.5 ± 38.6. At the end of the follow-up period, 69 patients had been discharged, and 15 were hospitalized (mean stay of 6 days). Older age and higher National Early Warning Score 2 were significant predictors of hospitalization at the first follow-up visit. One hospitalized patient died of septic shock. In the control group, the mean hospital stay was 8 days.
Conclusion:Adopting a “discharge and early revaluation” strategy appears to be safe, feasible, and may optimize hospital resources during the SARS-CoV-2 pandemic. 
            