Monoterpene glucosides from an aqueous extract of Monochasma savatieri
10.16438/j.0513-4870.2022-0757
- VernacularTitle:鹿茸草水提取物中的单萜苷类成分
- Author:
Chen LIU
1
;
Cheng-gen ZHU
1
;
Cheng-bo XU
1
;
Bin MU
2
;
Qing-lan GUO
1
;
Jian-gong SHI
1
Author Information
1. Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Harbin Kanglong Pharmaceutical Co., Ltd., Harbin 150025, China
- Publication Type:Research Article
- Keywords:
Scrophulariaceae;
italic>Monochasma savatieri;
aqueous extract;
monoterpene glucosides;
monochasides
- From:
Acta Pharmaceutica Sinica
2022;57(8):2405-2415
- CountryChina
- Language:Chinese
-
Abstract:
Eleven monoterpene glucosides were isolated from a water decoction of Monochasma savatieri by column chromatography over macroporous adsorbent resin, MCI resin, Sephadex LH-20, and HW-40C, combined with preparative TLC, reversed phase HPLC, and flash column chromatographic techniques. Their structures were elucidated by comprehensive analysis of spectroscopic data, along with acidic and enzymatic hydrolysis as well as electronic circular dichroism (ECD) and NMR calculations, including six new compounds (1-4, 7 and 8), named monochasides A-D, G and H, respectively. Comparing the reported data of 9-hydroxylinaloyl 3-O-β-D-glucoside (5), (6Z)-9-hydroxylinaloyl 3-O-β-D-glucoside (6), and kankanoside D1 (9) with those obtained in this study, the absolute configurations of 6 and 9 were proved for the first time. Other two compounds were identified as 8-hydroxygeraniol 1-O-β-D-glucopyranoside (10) and 8-hydroxygeraniol 8-O-β-D-glucopyranoside (11), respectively.
