A new diphenyl butanedione from Astragalus membranaceus of northern Shanxi
10.16438/j.0513-4870.2022-0148
- VernacularTitle:陕北膜荚黄芪中的一个新二苯基丁二酮
- Author:
Xiao-jun YANG
1
;
Chao WANG
1
;
Yun-peng JIA
1
;
Yue SUN
1
;
Huo-bing REN
2
Author Information
1. College of Chemistry and Chemical Engineering, Yan′an University, Yan'an 716000, China
2. Shaanxi Yuankang Traditional Chinese Medicine Industry Development Co., Ltd., Suide 718000, China
- Publication Type:Research Article
- Keywords:
italic>Astragalus membranaceus (Fisch.) Bge.;
chemical constituent;
iphenyl butanedione;
antitumor activity
- From:
Acta Pharmaceutica Sinica
2022;57(8):2430-2434
- CountryChina
- Language:Chinese
-
Abstract:
Seven compounds were isolated from Astragalus membranaceus of northern shaanxi by silica gel and Sephadex LH-20 column chromatographies. Their chemical structures were identified on the basis of their physical and chemical properties. These compounds were elucidated as astragaloside IV (1), formononetin (2), calycosin (3), 1-(4-hydroxyphenyl)-4-(2,4-hydroxyphenyl)-2-hydroxy-1,4-but anedione (4), (E)-4-methylcinnamic acid (5), quercetin (6), and uridine (7). Compound 4 is a new compound and compound 5 was isolated from the plants of Astragalus Linn. for the first time. The results of in vitro antitumor activity assay showed that compound 4 could inhibit the proliferation of A549 with IC50 values of 11.41 μmol·L-1.
