A Case of Antiresorptive Agent-Related Osteonecrosis of the Jaw Successfully Treated with Hochuekkito

VernacularTitle:補中益気湯が有効であった骨吸収抑制薬関連顎骨壊死の1例
Author: Yuzo FUKUSHIMA ¹ ; Hisao ITO ² ; Shugo TAGASHIRA ³ ; Shigeto YANAGIHARA ⁴ ; Yosuke NAKAMURA ⁵ ; Ryosuke FUJITA ⁶
Author Information

1. Fukushima Orthopaedic Clinic
2. Kitaoka Hospital, Division of Orthopedic Surgery
3. Inokuchi Hospital
4. Tagashu Online Clinic
5. Kinki University, Department of Dermatology
6. Tottori University, Department of Otorhinolaryngology
Keywords: ARONJ (Antiresorptive agent-related osteonecrosis of the jaw); hochuekkito
From:Kampo Medicine 2021;72(3):254-259
CountryJapan
Language:Japanese
Abstract: We herein report a case of 91-year-old woman with antiresorptive agent-related osteonecrosis of the jaw (ARONJ) developed during treatment for osteoporosis with intravenous ibandronate. Although she was treated with several antibiotics and had an incision for the drainage of a pus discharge at a dental clinic for two months after the onset of ARONJ, the discharge persisted. We then added hochuekkito to her treatment, which resulted in a gradual decreased in pus discharge and decrease in wound size and the wound resolved after approximately one month. ARONJ is considered a refractory disease, however, it was successfully treated with hochuekkito in this patient. ARONJ is also a rare condition and to our knowledge, this is considered to be the first case of ARONJ, which has been successfully treated with Kampo medicine.