Lipid markers and targets of coronary artery disease based on lipidomics
10.16438/j.0513-4870.2022-0280
- VernacularTitle:基于脂质组学技术发现冠心病的脂质标志物和治疗靶点
- Author:
Guan-lin YANG
1
;
Qiong ZHAI
2
;
Xin DONG
3
;
Ren BU
3
;
Pei-feng XUE
3
;
Fang-xin ZHAO
2
;
Jing-kun LU
2
Author Information
1. School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010010, China; Zaozhuang Cancer Hospital, Zaozhuang 277000, China
2. School of Basic Medicine, Inner Mongolia Medical University, Hohhot 010010, China
3. College of Pharmacy, Inner Mongolia Medical University, Hohhot 010010, China
- Publication Type:Research Article
- Keywords:
lipid molecule;
lipidomics;
coronary artery disease;
sensitive lipid marker;
therapeutic target
- From:
Acta Pharmaceutica Sinica
2022;57(7):2003-2011
- CountryChina
- Language:Chinese
-
Abstract:
Coronary artery disease is the leading cause of death worldwide, the coronary artery stenosis or occlusion caused by atherosclerosis leads to myocardial ischemia, hypoxia, or necrosis, that is main histopathological features of coronary artery disease. Atherosclerosis relates closely to abnormal lipid regulation, chronic inflammation, and endothelial dysfunction. Cardiac enzymes and high, low-density lipoprotein are currently used to diagnose a variety of coronary artery diseases, but the evidence is inadequate. Thus, new cardioprotective therapies are required to explore sensitive molecular markers for the prediction of cardiovascular events. Lipids have an important role in maintaining the myocardial cell structure as well as cardiac function. Lipidomics is a newly emerged discipline that studies lipids on a large scale. Recent advancements in lipidomics on coronary artery disease have shown that certain lipids, such as ceramide, sphingosine, lysophosphatidic acid, oxidized lipids, and so on, are associated with the clinical classification and characteristics of coronary artery disease. In addition, recent studies of lipid profiles of the cardiac, fat, liver, and other tissue samples in animal models also have provided a novel viewpoint. Given the increasing application of lipidomics techniques for coronary artery disease, we provide a review of lipidomics technology, sensitive lipid markers, recent studies of therapeutic targets, and drug discovery for coronary artery disease.
