Evaluation on the efficacy of moxifloxacin hydrochloride based on physiological pharmacokinetic models
10.16438/j.0513-4870.2022-0108
- VernacularTitle:基于生理药代动力学模型对盐酸莫西沙星有效性的研究
- Author:
Jie GAO
1
;
Fang FENG
2
;
Li-xin WANG
3
;
Xiao-meng CHONG
3
;
Chen WANG
3
;
Li-hui YIN
3
Author Information
1. National Institutes for Food and Drug Control, Beijing 102629, China; China Pharmaceutical University, Nanjing 210009, China
2. China Pharmaceutical University, Nanjing 210009, China
3. National Institutes for Food and Drug Control, Beijing 102629, China
- Publication Type:Research Article
- Keywords:
moxifloxacin hydrochloride;
physiologically based pharmacokinetic model;
efficacy;
pharmacodynamics
- From:
Acta Pharmaceutica Sinica
2022;57(7):2153-2157
- CountryChina
- Language:Chinese
-
Abstract:
This study is to establish and validation in vivo models of moxifloxacin based on the theory of physiologically based pharmacokinetics (PBPK), and then to predict the distribution of moxifloxacin in human venous return and organ such as lung, spleen and so on. The efficacy of moxifloxacin and its pharmaceutical preparations were quantified by comparing the pharmacokinetic parameters with the minimum inhibitory concentration of related pathogenic bacterium. The results showed that the anti-infection efficacy of pharmaceutical moxifloxacin preparation in the corresponding organs was basically the same. The PBPK model of moxifloxacin preparations can be more accurately described the pharmacokinetic of anti-infective drugs in human, it is suitable for the efficacy evaluation of anti-infective drugs and provides a strong basis for the corresponding scientific research and scientific supervision.
