Advances in the study of structural modification and biological activities of asiatic acid
10.16438/j.0513-4870.2022-0073
- VernacularTitle:积雪草酸的结构修饰与生物活性研究进展
- Author:
Bin LIU
1
;
Wen-qiang TANG
1
;
Hong-juan TONG
1
;
Zhou-jing ZHU
1
;
Chu TANG
2
Author Information
1. School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xianyang 712046, China; Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province, Xianyang 712046, China
2. School of Life Science and Technology, Xidian University, Xi'an 710126, China
- Publication Type:Research Article
- Keywords:
asiatic acid;
erivative;
structural modification;
biological activity;
structure-activity relationship
- From:
Acta Pharmaceutica Sinica
2022;57(7):1962-1976
- CountryChina
- Language:Chinese
-
Abstract:
Asiatic acid (AA) is a ursane pentacyclic triterpenoids, which possesses a wide range of pharmacological activities, such as anti-tumor, hypoglycemic, anti-inflammatory, anti-bacterial. Due to poor solubility and low bioavailability, clinical application of asiatic acid is limited. To address these defects, the structural modifications of AA have been carried out, and large numbers of AA-based derivatives with novel structure and eximious biological activity have been developed. In this paper, the research progress of structural modifications, biological activity, structure-activity relationship and mechanism studies in recent twenty years are reviewed, which provides reference for development of AA-related drugs.
