Consideration on the emerging of severe acute hepatitis cases with of unknown etiology in children worldwide.
10.3760/cma.j.cn112150-20220427-00423
- VernacularTitle:对当前全球部分国家出现的不明原因儿童急性严重肝炎病例的思考
- Author:
Zhen ZHU
1
;
Nai Ying MAO
1
;
Yan ZHANG
1
;
Wen Bo XU
1
Author Information
1. National Institute for Viral Diseases Control and Prevention, China CDC, NHC Key Laboratory of Medical Virology and Viral Diseases, WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, China.
- Publication Type:Journal Article
- From:
Chinese Journal of Preventive Medicine
2022;56():1-3
- CountryChina
- Language:Chinese
-
Abstract:
Since January 2022, severe acute hepatitis cases with unknown etiology in children have occurred in many countries in Europe and the United States, and 43.8% of the cases were positive for human adenovirus (HAdV), and some cases were identified as HAdV-41. However, more evidences including etiology, genomics, liver pathology, and immunohistochemistry are needed to determine the main cause of this outbreak. At present, due to the lack of systematic surveillance and research on hepatitis caused by HAdV infection, it is impossible to determine whether there are similar hepatitis cases occurred in China. It is urgent to carry out HAdV virolgocial surveillance based on clinical symptom, and potential risk of HAdV hepatitis should be studied as soon as possible according to the available relevant clinical, epidemiological and virological data, as well as risk factor information, which will provide scientific and technical support for the prevention and control of HAdV-related diseases.
