Antibiotic-induced Severe Neutropenia with Multidrug-Dependent Antineutrophil Antibodies Developed in A Child with Streptococcus pneumoniae Infection.
10.3346/jkms.2009.24.5.975
- Author:
Young Ho LEE
1
;
Ha Baik LEE
;
Jung Yun KIM
;
Yeon Jung LIM
;
Su A SHIN
;
Tae Hee HAN
Author Information
1. Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea. cord@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Neutropenia;
Antineutrophil Antibody;
Anti-Bacterial Agents
- MeSH:
Anti-Bacterial Agents/*therapeutic use;
Antibodies, Antineutrophil Cytoplasmic/*blood/immunology;
Autoantibodies/blood/immunology;
Drug Therapy, Combination;
Humans;
Infant;
Male;
Neutropenia/chemically induced/*diagnosis;
Pneumonia, Pneumococcal/complications/*drug therapy;
Tomography, X-Ray Computed
- From:Journal of Korean Medical Science
2009;24(5):975-978
- CountryRepublic of Korea
- Language:English
-
Abstract:
Drug-induced neutropenia (DIN), particularly that in which antibiotic-dependent antineutrophil antibodies have been detected, is a rare disorder. We report the case of a child with pneumococcal pneumonia, who experienced severe neutropenia during various antibiotic treatments. We detected 4 kinds (cefotaxim, augmentin, vancomycin, and tobramycin) of antibiotic-dependent antineutrophil antibodies by using the mixed passive hemagglutination assay (MPHA) technique with this child.
