Research progress in the prevention and treatment of diabetic retinopathy based on retinal neurovascular unit damage and its coupling imbalance
10.3980/j.issn.1672-5123.2022.8.14
- VernacularTitle:基于视网膜神经血管单元损伤及其耦联失衡防治糖尿病视网膜病变的研究进展
- Author:
Bao-Hua LI
1
;
Chao-Hong GUO
1
;
Cheng-Wei GUO
1
Author Information
1. Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
retinal neurovascular unit;
diabetic retinopathy;
coupling mechanism;
research progress
- From:
International Eye Science
2022;22(8):1309-1312
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR), one of the common complications of diabetes, is a major cause of blindness. Traditionally, DR has been considered primarily a microvascular disease, and as research has progressed, it is now believed that disruption of the neuro-glia-vascular unit(NVU)and imbalance in its coupling mechanisms(coupling)play a key role in the early onset of DR. Understanding the cellular and molecular basis of NVU and how diabetes alters normal cellular communication and disrupts the cellular environment is important for the early prevention and treatment of DR. This paper summarizes the retinal NVU and its involvement in the molecular mechanism of DR pathogenesis, DR treatment based on retinal NVU repair, and discusses the future prospects and problems of DR.
