Pay attention to the research on the mechanism of retinoblastoma and the methods of diagnosis and treatment
10.3760/cma.j.cn511434-20220315-00144
- VernacularTitle:重视视网膜母细胞瘤发生机制和诊疗方法研究
- Author:
Xianqun FAN
1
Author Information
1. 上海交通大学医学院附属第九人民医院眼科 上海市眼眶病眼肿瘤重点实验室,上海 200025
- Keywords:
Retinoblastoma;
Diagnosis;
Eye enucleation;
Chemoradiotherapy;
Chemotherapy, cancer, regional perfusion;
Editorial
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(3):173-177
- CountryChina
- Language:Chinese
-
Abstract:
Retinoblastoma (RB) is the most serious eye disease that causes blindness, disability and death in infant. Loss of tumor suppressor gene RB1 leads to tumorigenesis of RB. With continuous innovation and development of new methods, the management of retinoblastoma has experienced a dramatic change from enucleation, external radiotherapy, intravenous chemotherapy, to intra-arterial chemotherapy combined with local treatment, enabling a more favorable outcome for survival, salvage and vision. However, the pathogenesis of RB is unclear in many aspects, the rate of eyeball removal in children with advanced RB remains high, and the innovation of new treatment are needed to be further promoted. Therefore, the key to improve the overall treatment level of RB is to pay attention to the study on pathogenesis, early diagnosis and treatment, as well as strengthen multi-center clinical trials and translational medicine research.
