Total serum IgE in people immunized with human diploid cell rabies vaccines with different production processes
10.3760/cma.j.cn112309-20211215-00419
- VernacularTitle:不同生产工艺的人用狂犬病疫苗(人二倍体细胞)受试者血清总IgE分析
- Author:
Jingjing LIU
1
;
Cui LIU
;
Yan KONG
;
Yuhua LI
Author Information
1. 中国食品药品检定研究院虫媒病毒疫苗室，北京 102629
- Keywords:
Human rabies vaccine;
Human diploid cell;
Total IgE
- From:
Chinese Journal of Microbiology and Immunology
2022;42(5):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of different production processes on sensitization responses to human diploid cell rabies vaccines.Methods:This study randomly collected 360 serum samples in clinical trials of four rabies vaccines with different production processes. Total IgE levels at different time points were detected by ELISA. SPSS19.0 software was used for statistical analysis.Results:Total IgE test results showed that the seropositive rate was 20% (6/30) for all four vaccines. The lowest mean value of total IgE was 9 IU/ml and the highest was 210 IU/ml. Repeated measures analysis of variance showed that there was no significant difference in total IgE levels at different sampling time points ( P=0.284), and the total IgE level in people injected with multistep concentrated human diploid cell rabies vaccine was significantly below that in people immunized with Vero cell rabies vaccine ( P=0.024). Conclusions:Increasing the immune dosage of human rabies vaccine could not result in a rise in total IgE. Human diploid cell rabies vaccines had good safety as the production process could remove most of allergenic impurities.
