Progress in biological function and application of bacterial protein glycosylation
10.3760/cma.j.cn112309-20211008-00332
- VernacularTitle:细菌蛋白糖基化修饰的生物学功能及应用研究进展
- Author:
Xiao LI
1
;
Jingmin YAN
;
Xuhu MAO
Author Information
1. 陆军军医大学（第三军医大学）药学与检验医学系，临床微生物与免疫学教研室，重庆 400038
- Keywords:
Bacterial protein;
Glycosylation;
Biological function;
Conjugate vaccine
- From:
Chinese Journal of Microbiology and Immunology
2022;42(4):323-329
- CountryChina
- Language:Chinese
-
Abstract:
Bacteria play an important role in human health and disease. Their biological functions are often related to the glycans attached to the protein surface. In recent years, the glycosylation modification of bacterial proteins has attracted increasingly widespread attention. With the continuous development of synthetic biology and the in-depth research on glycosylation modification systems, some modification systems have been applied in engineered bacteria to play the role of protein modification independently, making it possible to "customized glycoproteins" . This paper reviewed the current status of research on the basic components, types and pathways of bacterial protein glycosylation modification as well as the biological function and application.
