Advance in postnatal catch-up growth and insulin resistance in small for gestational age infants
10.3760/cma.j.cn113903-20210524-00486
- VernacularTitle:小于胎龄儿追赶生长与胰岛素抵抗的研究进展
- Author:
Xin'ao LIN
1
;
Jimei WANG
Author Information
1. 复旦大学附属妇产科医院新生儿科，上海 200090
- Keywords:
Infant, small for gestational age;
Child development;
Insulin resistance
- From:
Chinese Journal of Perinatal Medicine
2022;25(2):150-153
- CountryChina
- Language:Chinese
-
Abstract:
Small for gestational age (SGA) infants usually result from fetal growth restriction. After eliminating harmful factors, catch-up growth occurs in most SGA as a compensatory mechanism of children's growth and development. Many studies conclude that catch-up growth could lead to insulin resistance early in life. However, the mechanism remains unclear, which results in a lack of clinical intervention to reduce or even avoid insulin resistance. This review sums up studies on catch-up growth and insulin resistance. It describes the possible mechanism of suppressed thermogenesis and catch-up fat, stress, inflammation, DNA methylation, etc., to provide a theoretical foundation for clinical practice.
