Clinical research progress of dual orexin receptor antagonist lemborexant in the treatment of insomnia
10.3760/cma.j.cn113694-20211008-00683
- VernacularTitle:双重食欲素受体拮抗剂lemborexant治疗失眠障碍临床研究进展
- Author:
Xiangxiang ZHAO
1
;
Zhongxin ZHAO
Author Information
1. 海军军医大学附属长海医院神经内科，上海 200433
- Keywords:
Sleep disorders;
Therapies, investigational;
Pharmacology;
Dual orexin receptor antagonist
- From:
Chinese Journal of Neurology
2022;55(6):659-664
- CountryChina
- Language:Chinese
-
Abstract:
In past two decades, understanding of the role of the orexin system in regulating sleep and wakefulness has increased rapidly. Lemborexant, as a dual orexin receptor antagonist, has been approved in some countries for the treatment of insomnia disorders. Existing studies have shown that its safety and tolerability are significantly superior to traditional hypnotic drugs, and it will be new option for treating insomnia disorders. This article reviews the pharmacology, clinical efficacy and safety of lemborexant.
