Advances in magnetic resonance imaging of impulsive-compulsive behavior in Parkinson′s disease
10.3760/cma.j.cn113694-20211009-00687
- VernacularTitle:帕金森病冲动强迫行为的磁共振成像研究进展
- Author:
Gaohua ZHAO
1
;
Lanxiao CAO
;
Guohua ZHAO
Author Information
1. 浙江大学医学院附属第四医院神经内科，义乌 322000
- Keywords:
Parkinson disease;
Impulse control disorders;
Magnetic resonance imaging;
Neuroimaging
- From:
Chinese Journal of Neurology
2022;55(5):544-550
- CountryChina
- Language:Chinese
-
Abstract:
Impulsive-compulsive behaviors (ICBs), one of the non-motor symptoms of Parkinson′s disease (PD), may be attributed to dopaminergic dysfunction and dopamine replacement therapy. At present, understanding of ICBs, mechanisms and exploration of treatment largely depend on neuroimaging research. Despite contradictions among the findings, most evidence indicated that PD patients with ICBs showed decreased thickness in frontal and temporal cortex and the volume of subcortical nuclei when compared to those without ICBs. And the occurrence of ICBs is associated with relatively preserved white-matter integrity in the brain regions involved in reward-related behaviors. This article will give an overview of the magnetic resonance research of PD related ICBs including cortical thickness, diffusion tensor imaging, resting state and task state functional magnetic resonance imaging analysis, which lays a foundation for further imaging studies, revealing the pathogenesis and exploring the potential treatment options.
