Neuromyelitis optica spectrum disorders
10.3760/cma.j.cn113694-20220127-00062
- VernacularTitle:视神经脊髓炎谱系疾病
- Author:
Weizhi WANG
1
;
Huabing WANG
Author Information
1. 哈尔滨医科大学附属第二医院神经科，哈尔滨 150086
- Keywords:
Neuromyelitis optica spectrum disorders;
Central nervous system;
Demyelinating diseases;
Aquaporin 4;
Optic neuritis;
Longitudinally extensive transverse m
- From:
Chinese Journal of Neurology
2022;55(5):511-519
- CountryChina
- Language:Chinese
-
Abstract:
Neuromyelitis optica spectrum disorders (NMOSD) is an immune mediated inflammatory demyelinating disease of the central nervous system. Optic neuritis and longitudinally extensive transverse myelitis are the main clinical signs, and the etiology is mainly related to aquaporin 4 (AQP4) antibody. AQP4 is the target antigen of immune attack. NMOSD is characterized by optic neuritis, longitudinally extended transverse myelitis, medulla area postrema syndrome, brainstem syndrome, diencephalic syndrome and cerebral syndrome. In recent years, the etiological mechanism, clinical diagnosis and monoclonal antibodies targeting new mechanisms of NMOSD have made great progress, which promoted the development of clinical neurology.
