Significance of Epstein-Barr virus-infected lymphocyte cell types in peripheral blood mononuclear cells in post-transplant lymphoproliferative disorder after pediatric liver transplantation
10.3760/cma.j.cn421203-20210720-00196
- VernacularTitle:EB病毒感染淋巴细胞类型在儿童肝移植术后淋巴增殖性疾病中的意义
- Author:
Ying LIU
1
;
Liying SUN
;
Zhijun ZHU
;
Lin WEI
;
Wei QU
;
Zhigui ZENG
Author Information
1. 首都医科大学附属北京友谊医院重症肝病科 国家消化系统疾病临床医学研究中心，北京 100050
- Keywords:
Liver transplantation;
Post-transplant lymphoproliferative disorder;
Epstein-Barr virus
- From:
Chinese Journal of Organ Transplantation
2022;43(1):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the characteristics and significance of Epstein-Barr virus-infected lymphocyte cell types in peripheral blood mononuclear cells(PBMC)in post-transplant lymphoproliferative disorder(PTLD)after pediatric liver transplantation.Methods:From June 2013 to March 2021, retrospective data analysis was performed for 14 pediatric liver transplant recipients with PTLD.The determination of EBV-DNA in PBMC, plasma and TBNK lymphocyte cells was analyzed.Results:EBV-DNA in PBMC showed a high viral load(>10 4 copies/ml)and plasma EBV-DNA was >10 3 copies/ml( n=8). There were dominant B-cell-type infection( n=12)and T/NK-cell-type infection( n=2). After treatment, EBV-DNA in PBMC and plasma turned negative in 7 patients with a decline( n=6)and an increase( n=1). EBV-DNA in B lymphocyte became negative( n=10)with a decline( n=3). In one case, EBV-DNA increased in T, B and NK cells with a high viral load.The remainders recovered after treatment.One case of hemophagocytic syndrome died from a progression of PTLD. Conclusions:A large majority of EBV-related PTLD are dominated by B-cell-type infection and a few belong to T or NK-cell-type infection.Patients with T/NK-cell-type infection have a worse response to therapy and poorer prognosis than those with B-cell-type infection.Determination of EBV-infected lymphocyte cell types is of vital research value for treatment and prognosis.
