Evaluation with time-zero biopsy in donors with acute kidney function injury and clinical effect after transplantation
10.3760/cma.j.cn421203-20210608-00163
- VernacularTitle:合并急性肾损伤供者供肾零点活检评估及移植后临床效果分析
- Author:
Kunlun ZHU
1
;
Lei LIU
;
Wenjun SHANG
;
Xinlu PANG
;
Zhigang WANG
;
Yonghua FENG
;
Junxiang WANG
;
Jinfeng LI
;
Xianlei YANG
;
Guiwen FENG
Author Information
1. 郑州大学第一附属医院肾移植科 450052
- Keywords:
Kidney transplantation;
Acute kidney injury;
Delayed graft function
- From:
Chinese Journal of Organ Transplantation
2021;42(12):717-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the time-zero biopsy of donor kidney with acute kidney injury(AKI)in organ donation donors and examine the clinical effect after transplantation.Methods:From May 2019 to May 2020, clinical data were retrospectively reviewed for 104 donors assessed by time-zero biopsy at First Affiliated Hospital, Zhengzhou University.According to the definition of AKI and Banff2016 criteria, the kidneys of 104 donors were grouped and evaluated for transplantation.And the post-transplantation effects of donor kidneys with different degrees of pathological changes were analyzed.Results:AKI occurred in 32/104 donors.Compared with non-AKI donors, statistically significant differences existed in degrees of renal interstitial fibrosis and acute renal tubular injury ( P<0.05). However, there were no significant differences in other pathological manifestations ( P>0.05). In AKI group, kidneys of 2 donors with Banff score>3 were abandoned; in non-AKI group, among 12 donors with Banff score>3, 1 donor kidney was abandoned due to a high degree of chronic diseases.No significant inter-group difference existed in creatinine value or estimated glomerular filtration rate(eGFR)( P>0.05). AKI group had a higher incidence of postoperative delayed graft function(DGF)and longer duration.There was no statistical significance in other complications ( P>0.05). Conclusions:AKI donor kidneys with pathological manifestations below moderate renal tubular injury and Banff score<3 are feasible for transplantation.Although renal function recovery is slow after transplantation, safe outcomes may be obtained.
