Clinicopathologic features and prognosis of appendendicular goblet cell adenocarcinoma
10.3760/cma.j.cn113855-20210831-00527
- VernacularTitle:阑尾杯状细胞腺癌的临床病理学特征及预后分析
- Author:
Yan XIA
1
;
Dan HU
;
Yan LIU
;
Ming ZHAO
;
Guoqing RU
Author Information
1. 浙江省人民医院 杭州医学院附属人民医院肿瘤中心病理科，杭州 310014
- Keywords:
Appendiceal neoplasms;
Goblet cells;
Adenocarcinoma;
Pathology,clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2022;37(5):330-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinicopathological characteristics, and prognosis of appendiceal goblet cell adenocarcinoma(GCA).Methods:The clinical and pathological data of 21 GCA cases were retrospectively analyzed, and their pathological morphology, immunohistochemical phenotype, genetic alteration and clinical treatment and prognosis were studied.Results:Most of the 21 patients showed appendicitis, with appendectomy alone or extensive resection of the tumor, followed by chemotherapy. There were 12 low-grade and 9 moderate and high-grade patients by pathological examination, and tumor cells express CEA, CK20, SATB-2, Syn(19/21), CgA(18/21), CD56(18/21), Ki67(+,10%-50%),and one patient had mutations in the BRAF gene.Depth of tumor infiltration ( r=0.716, P<0.001), and TNM stage ( r=0.816, P<0.001) were all positively correlated with the grade of GCA. After 19 to 98 months of follow-up, one patient relapsed and one patient died. Conclusions:Appendiceal GCA is a kind of tumor with bidirectional differentiation characteristics. Its morphology and biological behavior lineage are relatively broad, especially the high level is more aggressive, hence more active treatment should be adopted.
