Correlation between dementia with Lewy bodies and blood-brain barrier

VernacularTitle:路易体痴呆与血脑屏障
Author: Zhichao CHEN ¹ ; Lingyun MA ; Jinghuan GAN ; Shuai LIU ; Yanfeng LI ; Yong JI
Author Information

1. 首都医科大学附属北京天坛医院认知障碍性疾病科，北京　100070
Keywords: Dementia; Blood-Brain barrier; α-synuclein
From: Chinese Journal of Geriatrics 2022;41(5):600-604
CountryChina
Language:Chinese
Abstract: Dementia with Lewy bodies(DLB)is the second most common neurodegenerative dementia after Alzheimer's Disease(AD). This article will mainly elaborate the relationship between DLB and blood-brain barrier(BBB)from the following five aspects: (1)The structure and function of BBB; (2)In vivo assessment methods for the blood-brain barrier damage; (3)Evidence for the damage of blood-brain barrier in DLB; (4)The relationship between α-synuclein and the blood-brain barrier; (5)The relationship between APOE and the blood-brain barrier.Future research should focus on the pathogenesis of BBB damage in DLB patients, by which new drug targets for disease diagnosis and treatment may be found.