Research progress on DNA damage in aging-related diseases
10.3760/cma.j.issn.0254-9026.2022.01.022
- VernacularTitle:DNA损伤在衰老相关疾病中的研究进展
- Author:
Nan ZHANG
1
;
Qi ZHOU
;
Chen CHEN
;
Ying ZHANG
;
Huiping YUAN
;
Ze YANG
;
Zhu WU
;
Liang SUN
Author Information
1. 北京医院 国家老年医学中心 国家卫生健康委北京老年医学研究所 国家卫生健康委北京老年医学重点实验室 中国医学科学院老年医学研究院 100730
- Keywords:
Aging;
Molecular mechanism;
DNA damage;
Age-related diseases
- From:
Chinese Journal of Geriatrics
2022;41(1):104-107
- CountryChina
- Language:Chinese
-
Abstract:
DNA damage is one of the research hotspots in the field of aging and related diseases, because it can cause cell cycle arrest and apoptosis, accelerate the body's rate of aging and increase the risk of aging-related diseases.This review will summarize the mechanisms of DNA damage in cells, animal models and individuals and its associations with aging and aging-related diseases, including cancer, cardiovascular disease, Alzheimer's disease and premature aging syndromes.We aim to provide a theoretical framework for anti-aging research and clinical intervention in the treatment of aging-related diseases.
