Research advances on the role of mTOR signaling pathway in regulating autophagy in spinal cord injury

VernacularTitle:mTOR信号通路调控自噬在脊髓损伤中的作用研究进展
Author: Fuyao ZHOU ¹ ; Weike CHEN ; Guodong ZHAO ; Lingsheng KONG
Author Information

1. 济宁医学院临床医学院，济宁　272067
Keywords: Spinal cord injuries; Autophagy; mTOR signaling pathway
From: Journal of Chinese Physician 2022;24(3):469-472
CountryChina
Language:Chinese
Abstract: Traumatic spinal cord injury (SCI) has devastating effects on patients′ physical and mental health. Autophagy is widely involved in various physiological and pathological processes of the body and plays a key role in spinal cord injury. The mammalian target of rapamycin (mTOR) is the main regulator of autophagy. mTOR regulation of autophagy is closely related to the pathological process of spinal cord injury, and can effectively promote the recovery of spinal cord injury. Therefore, mTOR is a promising target for treatment of spinal cord injury. This article reviews the role of mTOR signal transduction pathway in the regulation of autophagy in spinal cord injury, in order to provide reference for follow-up research.