Application of immunological markers in the diagnosis and prediction of type 1 diabetes

VernacularTitle:免疫学标志物在1型糖尿病诊断及预测中的应用
Author: Yanyan QI ¹ ; Tao YANG ; Yong GU
Author Information

1. 南京医科大学第一附属医院内分泌科，南京　210029
Keywords: Diabetes mellitus, type 1; Immunological markers; Islet autoantibodies; T-lymphocytes
From: Journal of Chinese Physician 2022;24(2):190-195
CountryChina
Language:Chinese
Abstract: Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease mediated by T cells. Untreated T1DM deteriorate rapidly. Early prediction and diagnosis lead to early treatment and prognosis of patients. Immune system plays an important role in the destruction of β cells in T1DM patients, and the emergence of immunological markers has facilitated the diagnosis and prediction of T1DM. Based on the results of various cohort studies and clinical studies in recent years, this review comprehensively discusses the application of immunological markers in the prediction and diagnosis of T1DM from two aspects: humoral immune markers and cellular immune markers.