Efficacy of linezolid in the treatment of gram-positive coccal infections after chemotherapy in older adult patients with leukemia
10.3760/cma.j.issn1008-6706.2022.02.015
- VernacularTitle:利奈唑胺治疗老年白血病患者化疗后伴革兰阳性球菌感染的疗效观察
- Author:
Yajun WU
1
;
Zhigang QU
;
Qiulian LUO
Author Information
1. 义乌市中心医院血液科,义乌 322000
- Keywords:
Leukemia;
G + cocci infection;
Linezolid;
Resistance to infection;
Clinical efficacy;
Body temperature recovery;
Adverse reactions
- From:
Chinese Journal of Primary Medicine and Pharmacy
2022;29(2):225-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy and adverse reactions of linezolid in the treatment of gram-positive coccal infections after chemotherapy in older adult patients with leukemia.Methods:Ninety-two older adult patients with leukemia complicated by gram-positive coccal infections, who received treatment in Yiwu Central Hospital from January 2017 to December 2019, were included in this study. They were randomly assigned to receive routine anti-infection treatment (control group, n = 46) or linezolid treatment (observation group, n = 46). Clinical efficacy, the time required for body temperature restoring to normal, and medication time were compared between the two groups. Results:Total response rate was significantly higher in the observation group than in the control group [95.65% (44 /46) vs. 78.26% (36/46), χ2 = 6.13, P = 0.013]. The time required for body temperature restoring to normal and medication time in the observation group were (7.98 ± 1.04) days and (8.58 ± 1.31) days, respectively, which were significantly shorter than those in the control group [(8.85 ± 1.47) days, (9.46 ± 2.52) days, t = 3.27, 2.10, P = 0.001, 0.019). The incidence of adverse reactions was significantly lower in the observation group than in the control group [4.35% (2/46) vs. 19.57% (9/46), χ2 = 5.05, P < 0.05]. Conclusion:Linezolid is highly effective on gram-positive coccal infections after chemotherapy in older adult patients with leukemia. Linezolid treatment requires comparatively shorter time required for body temperature restoring to normal and shorter medication time and is safer than routine anti-infection treatment.
