Advance in mechanism and management study of vernal keratoconjunctivitis
10.3760/cma.j.cn115989-20220413-00159
- VernacularTitle:春季角结膜炎的发病机制及治疗研究进展
- Author:
Suxia LI
1
;
Weiyun SHI
Author Information
1. 山东第一医科大学附属眼科研究所 山东第一医科大学附属眼科医院 山东省眼科医院 山东省眼科学重点实验室-省部共建国家重点实验室培育基地 山东第一医科大学眼科学院，济南 250021
- Keywords:
Vernal keratoconjunctivitis;
Pathogenesis;
Therapy
- From:
Chinese Journal of Experimental Ophthalmology
2022;40(5):481-486
- CountryChina
- Language:Chinese
-
Abstract:
Vernal keratoconjunctivitis (VKC) is a chronic, bilateral allergic conjunctivitis common in school children.VKC is classified into palpebral-conjunctival type, limbal type and mixed type primarily based on clinical findings.Most allergic conjunctivitis does not impair vision, however, VKC probably causes visual impairment because of the involvement of cornea besides conjunctiva.Corneal lesions of VKC would lead to amblyopia in younger children.The term "vernal" in VKC indicates a seasonal onset, but 20%-60% patients are found onset throughout the year.In addition, misdiagnosis and improper treatment often lead to persistence or recurrence of VKC and other complications.Previous study has suggested that VKC is a hypersensitivity disease involved both type I and type IV, however, recent researchers found that immune factor, genetic factor and endocrine factor show close associations with the pathogenesis of VKC.The diagnosis of VKC depends on the clinical symptoms, pathological findings, infiltration of dendritic cells by laser scanning confocal microscopy and allergen tests.The treatment of VKC mainly focuses on symptom relief.In addition to anti-allergy, anti-inflammation and artificial tears, immunosuppressor has become a new trend.The pathogenesis and treatment progress of VKC are reviewed.
