Research progress of correlation between microRNA and the pathogenesis of cataract

VernacularTitle:MicroRNA与白内障发病相关性的研究进展
Author: Yadi PU ¹ ; Yuanbin LI
Author Information

1. 青岛大学附属烟台毓璜顶医院眼科，烟台　264000
Keywords: Non-coding RNA; MicroRNA; Cataract; Epithelial cells, lens
From: Chinese Journal of Experimental Ophthalmology 2022;40(5):475-480
CountryChina
Language:Chinese
Abstract: MicroRNA (miRNA) is a kind of small non-coding RNA, which can specifically bind to the 3' untranslated region of the target RNA, inducing the degradation or inhibiting the translation of the target mRNA, and ultimately affecting the important biological processes such as cell proliferation, differentiation, and apoptosis.Cataract, a leading blinding eye disease in the world, is a kind of disease that causes blindness because of lens opacification, including age-related cataracts, diabetic cataracts, congenital cataracts and posterior capsule opacification.In recent years, it has been found that many kinds of miRNA are expressed in lens and participate in the development of cataract, having significant influences on the proliferation, migration, epithelial-mesenchymal transition and apoptosis of lens epithelial cells, and take part in the occurrence and development of cataracts.The advances of different miRNAs in cataract were reviewed in this article so as to provide new ideas and methods for the prevention and treatment of cataract.