Perioperative diagnosis and treatment strategies of liver transplantation for liver cancer in precision medicine era
10.3760/cma.j.cn115610-20220110-00025
- VernacularTitle:精准医疗时代肝癌肝移植围手术期诊断与治疗策略
- Author:
Jian ZHOU
1
;
Yifeng HE
;
Xiaowu HUANG
;
Xinrong YANG
Author Information
1. 复旦大学附属中山医院肝外科 肝癌研究所 癌变与侵袭原理教育部重点实验室 上海市器官移植重点实验室，上海 200032
- Keywords:
Liver neoplasms;
Liver transplantation;
Precision medicine;
Biomarker;
Immune tolerance;
Recurrence prevention;
Diagnosis and treatment strategy
- From:
Chinese Journal of Digestive Surgery
2022;21(2):205-209
- CountryChina
- Language:Chinese
-
Abstract:
Tumor recurrence and metastasis after liver transplantation (LT) remains one of the most important factors that affect the outcome of LT for hepatocellular carcinoma (HCC). The diagnosis and treatment strategies in the era of precision medicine, including utilizing multi-omics, high-throughput gene sequencing analysis, big data and artificial intelligence to select the biomarkers which can accurately predict the prognosis after LT, evaluating the immune status comprehensively, inducing immune tolerance, providing effective prevention for patients at a high risk of recurrence with sensitive antitumor drugs and attaching importance to individualized treatment for recurrence and metastasis, may further improve the outcome of LT. Combined with experience and review of relevant research articles, the authors elaborate perioperative diagnosis and treatment strategies of LT for HCC, aiming to promote the application of precision medicine in the field of LT.
