Analysis of bacterial distribution and antibiotic resistance in children with severe pneumonia through bronchoalveolar lavage fluid
10.3760/cma.j.issn.1673-4912.2022.05.009
- VernacularTitle:通过支气管肺泡灌洗液分析儿童重症肺炎的病原菌分布与耐药情况
- Author:
Mingdong GAO
1
;
Shuqiong MIAO
;
Li YANG
;
Shuzhen ZHAO
;
Wenxiang WANG
;
Xiaoyan LEI
Author Information
1. 甘肃省人民医院儿科，兰州 730030
- Keywords:
Severe pneumonia;
Bacteria;
Antibiotic resistance rate;
Children
- From:
Chinese Pediatric Emergency Medicine
2022;29(5):363-367
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To realize the bacterial distribution and antibiotic resistance in children with severe pneumonia in this region.Methods:A total of 203 children with severe pneumonia diagnosed in Gansu Provincial People′s Hospital from April 2018 to March 2020 were divided into 0-1, 1-3, 3-7 and 7-14 years old groups.Bronchoalveolar lavage fluid was collected for bacterial culture and identification, and antibiotic susceptibility tests were performed.Results:The positive rate of pathogens was 69.5% (141/203), including 72.3% (102 strains) of Gram-negative bacteria and 30.5%(43 strains)of Gram-positive bacteria.The infection rates were highest in 0-1 years old group and the lowest in 7-14 years old group, which were 45.2%(19/42) and 16.9%(10/59), respectively.The infection rates of Haemophilus influenzae, Escherichia coli and Branhamella catarrhalis in the 1-3 years old group were 30.30%(10/33), 33.33% (11/33), and 21.21% (7/33), respectively, which showed significant differences compared with other groups( P<0.05). The infection rate of Streptococcus pneumoniae in the 0-1 years old group was 42.9%(18/42), which was significantly different compared with other groups ( P<0.001). The resistance rate of Haemophilus influenzae to trimethoprim/sulfamethoxazole was 89.5%(34/38), and the Streptococcus pneumoniae to trimethoprim/sulfamethoxazole and tetracycline were both 82.4%(28/34). The highest antibiotic resistance rate of Escherichia coli was 34.6%(9/26), and the Branhamella catarrhalis to clindamycin was 56.3%(9/16). Conclusion:The dominant bacteria for severe pneumonia in children are Haemophilus influenzae, Streptococcus pneumoniae, Escherichia coli and Branhamella catarrhalis.The bacterial infection rate is highest within 1 year old, but gradually decreases with the increase of age.Haemophilus influenzae and Streptococcus pneumoniae have severe resistance to several antibiotics.
