Clinical characteristics and nasopharyngeal bacteria profiles in children with respiratory syncytial virus bronchiolitis
10.3760/cma.j.cn101070-20210315-00306
- VernacularTitle:呼吸道合胞病毒感染毛细支气管炎患儿鼻咽部细菌类别与临床特征研究
- Author:
Jia ZHANG
1
;
Huiming SUN
;
Shuxiang LI
;
Ting WANG
;
Jun ZHANG
;
Yuan GAO
;
Linlin QU
;
Longbing HE
;
Chuangli HAO
Author Information
1. 宿迁市第一人民医院儿科，宿迁 223800
- Keywords:
Respiratory syncytial virus;
Bronchiolitis;
Nasopharynx bacteria;
Disease severity
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(10):738-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the detection of potentially pathogenic bacteria (PPB) in the nasopharynx of children with respiratory syncytial virus (RSV) bronchiolitis and the influence of PPB types on disease severity.Methods:In this retrospective cohort study, clinical data of patients hospitalized for RSV bronchiolitis at Department of Respiratory Medicine, Children′s Hospital of Soochow University between January 1, 2017 and December 31, 2019 were retrospectively analyzed.The virus, Mycoplasma pneumoniae and bacteria in nasopharyngeal secretion of children were detected.They were classified into <3 months group, 3-<6 months group, 6 months-<1 year group and 1-2 years group based on the age.In addition, they were further classified into RSV infection group, RSV+ G + group, RSV+ G - group and RSV+ G + + G - group based on detected PPB in the nasopharynx.Comparison of RSV + PPB frequency between groups was performed by Chi- squared test, clinical characteristics were compared by using Mann- Whitney U test. Results:A total of 280 patients with RSV bronchiolitis were included in the study, involving 113 cases (40.4%) with PPB in the nasopharynx.The most-common detection bacterium was Streptococcus pneumoniae.The detection rate of Streptococcus pneumoniae increased with age ( χ2=12.609, P=0.005), while that of Staphylococcus aureus decreased with age ( χ2=8.387, P=0.034). Compared with RSV group, patients in RSV+ G - group had a longer length of stay, higher rate of fever and shortness of breath, higher oxygen supplement and higher C-reactive protein (CRP) (all P<0.05). Compared with RSV group, patients in RSV+ G + group were older, and they had higher rate of fever, higher percentage of neutrophil, lower percentage of lymphocyte and higher CRP (all P<0.05). Conclusions:PPB in nasopharynx can be detected in about 40% of children hospitalized with RSV bronchiolitis, and nasopharynx complicated with PPB infection may affect the severity of RSV bronchiolitis.
