Influencing factors of 13C-urea breath test in the diagnosis of Helicobacter pylori infection in children
10.3760/cma.j.cn101070-20201117-01770
- VernacularTitle:13C-尿素呼气试验诊断儿童幽门螺杆菌感染相关影响因素
- Author:
Tian GENG
1
;
Zhongyue LI
Author Information
1. 重庆医科大学附属儿童医院消化科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿童发育重大疾病国家国际科技合作基地，儿科学重庆市重点实验室，重庆 400014
- Keywords:
13C-urea breath test;
Helicobacter pylori;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(7):552-555
- CountryChina
- Language:Chinese
-
Abstract:
The 13C-urea breath test is the most widely applied non-invasive test to diagnose Helicobacter pylori (Hp) infection in children.The fasting time, dose and formulation of labeled urea, type of test meal, time of breath collection, device to detect breath samples, cut-off value of exhaled 13CO 2/ 12CO 2 breath delta value and the interpretation of results have been modified to improve the accuracy.The 13C-urea breath test possesses a good perfor-mance in diagnosing Hp infection and evaluating the eradication of infection after treatment in children.However, the high false-positive results in young children are caused by oral flora, endogenous CO 2 and fixed dose of labeled urea.In addition, taking proton pump inhibitors, antibiotics and bismuth before test, low bacterial density and peptic ulcer bleeding will lead to false negative results.This study aims to review the influencing factors of 13C-urea breath test in the diagnosis of Hp infection in children.
