Research advances on exosome-derived microRNA related to treatment of cardiovascular diseases in children
10.3760/cma.j.cn101070-20200911-01498
- VernacularTitle:外泌体源性微小RNA在儿童心血管系统疾病治疗中的研究进展
- Author:
Jingjing LAN
1
;
Mingguo XU
Author Information
1. 遵义医科大学珠海校区，珠海 519041
- Keywords:
Exosomes;
microRNA;
Cardiovascular disease;
Research progress;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2022;37(5):393-397
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, exosomes have been gradually concerned, and exosome-derived microRNA (exo-microRNA) have been widely used in the early diagnosis as non-invasive biomarkers with a great potential.There are abundant exosomes in the blood released by platelets, arterial endothelial cells and other cell types, and the external membrane of exosomes also has the unique advantages of protecting exo-microRNA and other contents from biological enzyme hydrolysis and stabilizing them in human body fluids.Therefore, exosomes and exo-microRNA are of great significance in the early diagnosis of cardiovascular diseases, cell regeneration, and cardiac protection.This review focuses on the structure and biogenesis of exosomes, the mechanism of exo-microRNA, and the relevant research progress of exo-microRNA in treatment of pediatric cardiovascular diseases in recent years.
